Pain, loss of sensation, cramps, weakness and other symptoms are part of the syndrome.

Known causes of neuropathy include diabetes, compression of nerves in both upper and lower limbs (carpal/tarsal tunnel syndromes), HIV infection and cancer chemotherapy among others. Pain in some of these disorders can be difficult to treat.

A detailed evaluation and correct diagnosis are necessary prior to establishing a plan of treatment.

Treatment approaches include physical therapy modalities and drugs which are mostly used for pain relief.

Ultimately, and if conventional treatment fails, decompressive surgery can relieve pain while restoring sensation. These procedures can help prevent ulcers and amputations in diabetics and relieve pain in chemotherapy induced neuropathy.

The operation is relatively simple and is performed in an outpatient center. It is effective in approximately 85% of cases.